Effect‏ ‏of consuming Pandora Fish‏ ‏‎(Pagelluserythrinus) and cod ‎liver‏ ‏oil on‏ ‏prothrombin time and international normalized ratio

Abstract

Consumption of fish and cod liver oil (CLO) are important due to their content group of polyunsaturated fatty acids known as omega -3. This study was designed to determine the effect of consuming Pandora fish and intake of Cod Liver Oil) COL) on the level of blood aggregation (Prothrombin time) (PT) and International Normalized Ratio (INR). The study was performed on 42 Volunteers aged 25 – 60 years live in Tripoli, Libya. They were divided to three groups, each group included 14 persons (7 males and 7 females). The first group (Fish Group) (FG) were given 500 g / week of common Pandora fish, the second group (Cod Liver Oil Group) (CLOG) were given 3.3 g / week of COL with the normal diets for the two groups, while the third group (Control Group) (CG) was on diet in which any source of omega–3 fatty acids was excluded. The study lasted for 60 days, during which blood samples were withdrawn once every two weeks to estimate PT and INR. The analyses of the two parameters were performed 5 times with a rate of once every two weeks. Results showed that consumption of Pandora fish caused a significant reduction in PT with comparison to the CG, whereas this effect was not noticed with taking CLO doses. And it was noticed that there is significant effect for CLO to reduce INR with comparison CG but fish mail showed no significant effect on INR. On other hand, with regard to the sex effect on PT and INR, results indicated there was tendency to increase PT in males more than females and also with the INR. In addition, results indicated males or females of FG or males of CLOG a significant reduction in PT with comparison to males and females of CG but no effect to this interaction was observed on INR. In case of meal and time period interaction, no effect was shown either on PT or INR for Pandora fish or CLO.